The Study Findings table contains information on the genetic findings of a particular NESHIE or CP genetic study. Variants with statistically-significant associations with NESHIE or CP have p-values < 0.05. Odds ratio values quantify the strength of association of a variant allele with NESHIE or CP.
Paper: Gibson et al., 2005
DOI: 10.1016/j.ajog.2005.02.107
Study population description: Australian (Caucasian); 443 children with CP and 883 children without CP
Regional classification: Oceania
Sequencing or genotyping methods: PCR amplification of the polymorphic regions, determination of the polymorphic bases using a ABI Prism SNaPshot Multiplex Kit, analysis of products on a DNA sequencer (ABI 3700)
| Variant | Reported allele or genotype | Condition | Condition description | Disease status | Odds ratio | P value |
|---|---|---|---|---|---|---|
| rs1801133 | AA genotype | CP | 32-36 weeks gestation | Susceptibility | 2.550 | <0.05000000 |
| rs1801133 | GA genotype | CP | 32-36 weeks gestation | Susceptibility | 1.910 | <0.05000000 |
| rs1801131 | TG genotype | CP | Protective for diplegia, 32-36 weeks gestation | Susceptibility | 0.160 | <0.05000000 |
| rs1801133 | AA genotype | CP | Diplegia, < 32 weeks gestation | Susceptibility | 2.760 | <0.05000000 |
| rs1801133 | GA genotype | CP | Diplegia | Susceptibility | 1.580 | <0.05000000 |
| rs1801131 | GG genotype (vs TG) | CP | Protective for quadriplegia | Susceptibility | 0.330 | <0.05000000 |