The Study Findings table contains information on the genetic findings of a particular NESHIE or CP genetic study. Variants with statistically-significant associations with NESHIE or CP have p-values < 0.05. Odds ratio values quantify the strength of association of a variant allele with NESHIE or CP.
Paper: Esih et al., 2021
Study population description: Slovenian; 44 HIE babies with moderate to severe (n = 18) and normal to mild magnetic resonance imaging findings (n = 26)
Regional classification: Europe
Sequencing or genotyping methods: Genotyping using fluorescent-based competitive allele-specific polymerase chain reaction assay
| Variant | Reported allele or genotype | Condition | Condition description | Disease status | Odds ratio | P value |
|---|---|---|---|---|---|---|
| rs1001179 | CT + TT genotype | NESHIE | Normal magnetic resonance imaging presentation | Severity | 0.390 | 0.03400000 |
| rs1143623 | C allele | NESHIE | Moderate to severe magnetic resonance imaging presentation | Severity | 3.780 | 0.04000000 |
| rs1143623 | C allele | NESHIE | Basal ganglia damage | Severity | 3.960 | 0.03900000 |
| rs1143623 | C allele | NESHIE | posterior limb of internal capsule damage | Severity | 5.670 | 0.00900000 |
| rs16944 | TC + TT genotype | NESHIE | posterior limb of internal capsule damage | Severity | 3.710 | 0.04000000 |
| rs1071676 | GC + CC genotype | NESHIE | Less white matter damage | Severity | 0.180 | 0.01100000 |
| rs2043211 | T allele | NESHIE | Protective against cortex damage | Severity | 0.150 | 0.03100000 |
| rs2043211 | AT + TT genotype | NESHIE | Protective against severe magnetic resonance imaging presentation | Severity | None | 0.04800000 |
| rs2043211 | T allele | NESHIE | Protective against brainstem damage | Severity | 0.070 | 0.02000000 |
| rs2043211 | AT + TT genotype | NESHIE | Protective against moderate/severe magnetic resonance imaging presentation | Severity | 0.260 | 0.04000000 |