Gene: TNF
Cytoband position: 6p21.3
OMIM: 191160
RVIS score: -0.03
RVIS percentage: 51.40
| Phenotype name | HPO ID | Alternative HPO ID | Phenotype description |
|---|---|---|---|
| Abnormality of the digestive system | HP:0025031 | None | None |
| Abnormality of the respiratory system | HP:0002086 | None | An abnormality of the respiratory system, which include the airways, lungs, and the respiratory muscles. |
| Asthma | HP:0002099 | HP:0002112 | Asthma is characterized by increased responsiveness of the tracheobronchial tree to multiple stimuli, leading to narrowing of the air passages with resultant dyspnea, cough, and wheezing. |
| Headache | HP:0002315 | HP:0001354 | Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve. |
| Abnormality of the immune system | HP:0002715 | HP:0010986 | An abnormality of the immune system. |
| Abnormal respiratory system physiology | HP:0002795 | None | None |
| Abnormality of digestive system physiology | HP:0025032 | None | A functional anomaly of the digestive system. |
| Sound sensitivity | HP:0025112 | None | Decreased tolerance to sound. |
| Abnormality of immune system physiology | HP:0010978 | None | A functional abnormality of the immune system. |
| Abdominal symptom | HP:0011458 | None | A subjective manifestation of disease localized to the abdomen. |
| Abnormal eye physiology | HP:0012373 | None | A functional anomaly of the eye. |
| Abnormal nervous system physiology | HP:0012638 | None | A functional anomaly of the nervous system. |
| Autosomal dominant inheritance | HP:0000006 | HP:0001463 | A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele. |
| Abnormality of the eye | HP:0000478 | None | Any abnormality of the eye, including location, spacing, and intraocular abnormalities. |
| Abnormality of vision | HP:0000504 | None | Abnormality of eyesight (visual perception). |
| Photophobia | HP:0000613 | None | Excessive sensitivity to light with the sensation of discomfort or pain in the eyes due to exposure to bright light. |
| Abnormality of the nervous system | HP:0000707 | HP:0006987 | An abnormality of the nervous system. |
| Behavioral abnormality | HP:0000708 | HP:0002456 | An abnormality of mental functioning including various affective, behavioural, cognitive and perceptual abnormalities. |
| Multifactorial inheritance | HP:0001426 | HP:0001472 | A mode of inheritance that depends on a mixture of major and minor genetic determinants possibly together with environmental factors. Diseases inherited in this manner are termed complex diseases. |
| Vomiting | HP:0002013 | None | Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions. |
| Nausea | HP:0002018 | None | A sensation of unease in the stomach together with an urge to vomit. |
| Immunologic hypersensitivity | HP:0100326 | None | Immunological states where the immune system produces harmful responses upon reexposure to sensitising antigens. |
| Migraine | HP:0002076 | HP:0007194 | Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms. |
| Migraine without aura | HP:0002083 | None | Repeated headache attacks lasting 4-72 h fulfilling at least two of the following criteria: 1) unilateral location, 2) pulsating quality, 3) moderate or severe pain intensity, and 4) aggravation by or causing avoidance of routine physical activity such as climbing stairs. Headache attacks are commonly accompanied by nausea, vomiting, photophobia, or phonophobia. |
| Phonophobia | HP:0002183 | None | An abnormally heightened sensitivity to loud sounds. |
| Nausea and vomiting | HP:0002017 | None | Nausea is a commonly encountered symptom that has been defined as an unpleasant painless subjective feeling that one will imminently vomit. Vomiting has been defined as the forceful expulsion of the contents of the stomach, duodenum, or jejunum through the oral cavity. While nausea and vomiting are often thought to exist on a temporal continuum, this is not always the case. There are situations when severe nausea may be present without emesis and less frequently, when emesis may be present without preceding nausea. |
| Migraine with aura | HP:0002077 | None | A type of migraine in which there is an aura characterized by focal neurological phenomena that usually proceed, but may accompany or occur in the absence of, the headache. The symptoms of an aura may include fully reversible visual, sensory, and speech symptoms but not motor weakness. Visual symptoms may include flickering lights, spots and lines and/or loss of vision and/or unilateral sensory symptoms such as paresthesias or numbness. At least one of the symptoms of an aura develops gradually over 5 or more minutes and/or different symptoms occur in succession. |